Cam Lo district is located in the central area of Quang Tri province , at 16⁰41 ' - 16⁰53' north latitude, 106⁰50' - 107⁰06' east longitude. Bordered by Gio Linh to the north ; Trieu Phong to the south; Dong Ha city by the south and Đakrông district on the west, Cam Lo is located on the intersection of critical traffic routes, that are : National highway 1A; Ho Chi Minh road; Highway 9 - inter-Asian routes linking Vietnam - Laos - Thailand and other regional countries.

Cam Lo district has natural area of 367.4 km2, accounting for 8% of the Quang Tri province. The area is considered as the northwest gateway of Dong Ha city. Ethnic minorities currently living here are including Kinh, Bru - Van Kieu.

Cam Lo is administratively divided into a main town of Cam Lo and 8 communes of Cam An, Cam Chinh, Cam Hieu Nghia Cam, Cam Thanh, Cam Thanh, Cam Thuy, Cam Tuyen. Statistic after survey , clearance and risk education activities.